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KMID : 0624620100430090614
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BMB Reports
2010 Volume.43 No. 9 p.614 ~ p.621
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Propamidine decreas mitochondrial complex III activity of Botrytis cinerea
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Wu Fangli
Jin Weibo
Feng Juntao
Chen Anliang
Ma Zhiqing
Zhang Xing
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Abstract
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Propamidine, an aromatic diamidine compound, is widely used as an antimicrobial agent. To uncover its mechanism on pathogenetic fungi, Botrytis cinerea as an object was used to investigate effects of propamidine in this paper. The transmission electron microscope results showed that the mitochondrial membranes were collapsed after propamidine treatment, followed that mitochondria were disrupted. Inhibition of whole-cell and mitochondrial respiration by propamidine suggested that Propamidine is most likely an inhibitor of electron transport within Botrytis cinerea mitochondria. Furthermore, the mitochondrial complex III activity were inhibited by propamidine.
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KEYWORD
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Botrytis cinerea, Mitochondria complex, Propamidine, Respiration function, Ultrastructure
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